A Framework for Analyzing Knowledge Utilization in Social Work Practice

Methodological and conceptual limitations have resulted in knowledge being defined so narrowly that we accept the inaccurate conclusion that social workers fail to utilize knowledge. This article seeks to rectify this problem by clarifying the concept of knowledge utilization in social work practice. Toward this end a framework is proposed that makes explicit the philosophy of science and practice assumptions germane to the use of knowledge in practice

The Diffusion of Humans and Cultures in the Course of the Spread of Farming

The most profound change in the relationship between humans and their environment was the introduction of agriculture and pastoralism. [....] For an understanding of the expansion process, it appears appropriate to apply a diffusive model. Broadly, these numerical modeling approaches can be catego- rized in correlative, continuous and discrete. Common to all approaches is the comparison to collections of radiocarbon data that show the apparent wave of advance of the transition to farming. However, these data sets differ in entry density and data quality. Often they disregard local and regional specifics and research gaps, or dating uncertainties. Thus, most of these data bases may only be used on a very general, broad scale. One of the pitfalls of using irregularly spaced or irregularly documented radiocarbon data becomes evident from the map generated by Fort (this volume, Chapter 16): while the general east-west and south-north trends become evident, some areas appear as having undergone anomalously early transitions to farming. This may be due to faulty entries into the data base or regional problems with radiocarbon dating, if not unnoticed or undocumented laboratory mistakes.Comment: 20 pages, 5 figures, submitted to Diffusive Spreading in Nature, Technology and Society, edited by Armin Bunde, J\"urgen Caro, J\"org K\"arger, Gero Vogl, Chapter 1

Relationship between dielectric properties and critical behavior of the electric birefringence in binary liquid mixtures

We present experimental results on the critical exponent ψEKE describing the divergence of the Kerr constant of binary liquid mixtures near the critical consolute point. We show that the measured value of ψEKE agrees with the theoretical prediction only if the measurement is performed with a mixture of two liquids presenting a small mismatch in the dielectric constant, and that the measured ψEKE grows as the dielectric constant mismatch increases. Such findings are consistent with a recent model which assumes that the elongation of critical fluctations along the direction of the electric field can become so strong that fluctuations in the direction perpendicular to the electric field may cross over from Ising to mean-field behavior

Negative length orbits in normal-superconductor billiard systems

The Path-Length Spectra of mesoscopic systems including diffractive scatterers and connected to superconductor is studied theoretically. We show that the spectra differs fundamentally from that of normal systems due to the presence of Andreev reflection. It is shown that negative path-lengths should arise in the spectra as opposed to normal system. To highlight this effect we carried out both quantum mechanical and semiclassical calculations for the simplest possible diffractive scatterer. The most pronounced peaks in the Path-Length Spectra of the reflection amplitude are identified by the routes that the electron and/or hole travels.Comment: 4 pages, 4 figures include

An amphitropic cAMP-binding protein in yeast mitochondria

ABSTRACT: We describe the first example of a mitochondrial protein with a covalently attached phos-phatidylinositol moiety acting as a membrane anchor. The protein can be metabolically labeled with both stearic acid and inositol. The stearic acid label is removed by phospholipase D whereupon the protein with the retained inositol label is released from the membrane. This protein is a cAMP receptor of the yeast Saccharomyces cereuisiae and tightly associated with the inner mitochondrial membrane. However, it is converted into a soluble form during incubation of isolated mitochondria with Ca2+ and phospholipid (or lipid derivatives). This transition requires the action of a proteinaceous, N-ethylmaleimide-sensitive component of the intermembrane space and is accompanied by a decrease in the lipophilicity of the cAMP receptor. We propose that the component of the intermembrane space triggers the amphitropic behavior of the mitochondrial lipid-modified CAMP-binding protein through a phospholipase activity. Only in recent years specific fatty acids have been recog-nized to play important roles in the association of proteins with membranes. Both noncovalent and covalent interactions be-tween fatty acids and proteins have been reported. Among the latter are GTP-binding proteins (Molenaar et al., 1988)

Precise Measurement of the Pi+ -> Pi0 e+ nu Branching Ratio

Using a large acceptance calorimeter and a stopped pion beam we have made a precise measurement of the rare Pi+ -> Pi0 e+ Nu,(pi_beta) decay branching ratio. We have evaluated the branching ratio by normalizing the number of observed pi_beta decays to the number of observed Pi+ -> e+ Nu, (pi_{e2}) decays. We find the value of Gamma(Pi+ -> Pi0 e+ Nu)/Gamma(total) = [1.036 +/- 0.004(stat.) +/- 0.004(syst.) +/- 0.003(pi_{e2})] x 10^{-8}$, where the first uncertainty is statistical, the second systematic, and the third is the pi_{e2} branching ratio uncertainty. Our result agrees well with the Standard Model prediction.Comment: 4 pages, 5 figures, 1 table, revtex4; changed content; updated analysi

The Tolman Surface Brightness Test for the Reality of the Expansion. IV. A Measurement of the Tolman Signal and the Luminosity Evolution of Early-Type Galaxies

We review a sample of the early literature in which the reality of the expansion is discussed, explain Hubble's reticence to accept the expansion as real, and contrast the Tolman surface brightness test with three other modern tests. We search for the Tolman surface brightness depression with redshift using the Hubble Space Telescope (HST) data from Paper III for 34 early-type galaxies from the three clusters Cl 1324+3011 (z=0.76), Cl 1604+4304 (z=0.90), and Cl 1604+4321 (z=0.92). Depressions of the surface brightness relative to the zero-redshift fiducial lines in the mean surface brightness, log linear radius diagrams of Paper I are found for all three clusters. Expressed as the exponent, n, in 2.5 log (1 + z)^n mag, the value of n for all three clusters is n = 2.59 +/- 0.17 in the R band and 3.37 +/- 0.13 in the I band for a q_o = 1/2 model. The sensitivity of the result to the assumed value of q_o is shown to be less than 23% between q_o = 0 and +1. For a true Tolman signal with n = 4, the luminosity evolution in the look-back time, expressed as the exponent in 2.5 log (1+z)^(4-n) mag, must then be between 1.72 to 1.19 in the R band and 0.94 to 0.45 in the I band. We show that this is precisely the range expected from the evolutionary models of Bruzual & Charlot. We conclude that the Tolman surface brightness test is consistent with the reality of the expansion. We have also used the high-redshift HST data to test the ``tired light'' speculation for a non-expansion model for the redshift. The HST data rule out the ``tired light'' model at a significance level of better than 10 sigma.Comment: 36 pages, 6 figures; accepted for publication in the Astronomical Journa

CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells

Glioblastoma (GBM) is one of the most aggressive types of cancer with limited therapeutic options and unfavorable prognosis. Stemness and non-classical epithelial-to-mesenchymal transition (ncEMT) features underlie the switch from normal to neoplastic states as well as resistance of tumor clones to current therapies. Therefore, identification of ligand/receptor systems maintaining this privileged state is needed to devise efficient cancer therapies. In this study, we show that the expression of CD95 associates with stemness and EMT features in GBM tumors and cells and serves as a prognostic biomarker. CD95 expression increases in tumors and with tumor relapse as compared with non- tumor tissue. Recruitment of the activating PI3K subunit, p85, to CD95 death domain is required for maintenance of EMT-related transcripts. A combination of the current GBM therapy, temozolomide, with a CD95 inhibitor dramatically abrogates tumor sphere formation. This study molecularly dissects the role of CD95 in GBM cells and contributes the rational for CD95 inhibition as a GBM therapy